梁静：研究员，博士生导师

研究方向：

表观遗传调控在发育和肿瘤中的分子机制

联系方式：

电话：010-82801608（办公室）；010-82801397（实验室）

办公地址：生化楼323

Email：liang_jing@bjmu.edu.cn

简介：主要研究表观遗传因子尤其是组蛋白修饰的writer/eraser/reader蛋白在基因转录调控、复制、DNA损伤修复等染色质事件中的分子机能，及其如何参与机体发育及肿瘤发生发展。以第一作者或责任作者身份在《Molecular Cell》、《Nature Communications》、《Annual Review of Physiology》、《EMBO Reports》、《Oncogene》和《Journal of Molecular Cell Biology》等主流学术期刊发表论文，并作为合作作者在《Nature》、《Nature Genetics》、《Cell》、《Cancer Cell》、《Molecular Cell》、《PNAS》等发表论文21篇。

简历:

博士：美国马里兰大学细胞与分子生物学系

硕士：北京医科大学人民医院儿科

本科：北京医科大学临床医学系

　　

获得基金：

科技部973课题（2014），305.8万元

国家自然基金委面上项目（2010，2014，2016，2019），共237.8万

教育部新世纪人才支持计划（2010），50万

科技部重大慢病研究计划课题，骨干成员（2016）

代表性论文：

1. Shumeng Liu, Huajing Yu, Yongqing Liu, Xinhua Liu, Yu Zhang, Chen Bu, Shuai Yuan, Zhe Chen, Guojia Xie, Wanjin Li, Bosen Xu, Jianguo Yang, Lin He, Tong Jin, Yundong Xiong, Luyang Sun, Xiaohui Liu, Chunsheng Han, Zhongyi Cheng, Jing Liang*, and Yongfeng Shang*. Chromodomain protein CDYL acts as a crotonyl-CoA hydratase to regulate histone crotonylation and spermatogenesis. Molecular Cell,67(5):853-866, 2017.

2. Yongqing Liu^#, Shirong Lai^#, Weining Ma, Wei Ke, Chan Zhang, Shumeng Liu, Yu Zhang, Fei Pei, Shaoyi Li, Ming Yi, Yousheng Shu, Yongfeng Shang, Jing Liang*, and Zhuo Huang*. CDYL suppresses epileptogenesis through repression of axonal Nav1.6 sodium channel expression. Nature Communications, 8(1):355. doi: 10.1038/s41467-017-00368-z, 2017.

3. Guojia Xie, Xinhua Liu, Yu Zhang, Wanjin Li, Shumeng Liu, Zhe Chen, Bosen Xu, Jianguo Yang, Lin He, Zihan Zhang, Tong Jin, Xia Yi, Luyang Sun, Yongfeng Shang, and Jing Liang*. UTX promotes hormonally responsive breast carcinogenesis through feed-forward transcription regulation with estrogen receptor. Oncogene, 36 (39): 5497-5511, 2017.

4. Yongqing Liu, Shumeng Liu, Shuai Yuan, Huajing Yu, Yu Zhang, Xiaohan Yang, Guojia Xie, Zhe Chen, Wanjin Li, Bosen Xu, Luyang Sun, Yongfeng Shang, and Jing Liang*. Chromodomain protein CDYL is required for transmission/restoration of repressive histone marks. Journal of Molecular Cell Biology, 9(3):178-194, 2017. Cover story.

5. Cai Qi, Shumeng Liu, Rui Qin, Yu Zhang, Guoqiang Wang, Yongfeng Shang, Yun Wang* and Jing Liang*. Coordinated regulation of dendrite arborization by epigenetic factors CDYL and EZH2. Journal of Neuroscience, 34: 4494-4508, 2014.

6. Yu zhang, Jing Liang* and Qian Li*. Coordinated regulation of retinoic acid signaling pathway by KDM5B and polycomb repressive complex 2. Journal of Cellular Biochemistry, 115: 1528-1538, 2014.

7. Xiaohan Yang, Jianguo Yang, Lei Li, Luyang Sun, Xia Yi, Xiao Han, Wenzhe Si, Ruorong Yan, Zhe Chen, Guojia Xie, Wanjin Li, Yongfeng Shang, and Jing Liang*. PAAT, a novel ATPase and trans-regulator of mitochondrial ABC transporters, is critically involved in the maintenance of mitochondrial homeostasis. FASEB Journal, 28:4821-34, 2014.

8. Yu Zhang, Xiaohan Yang, Bin Gui, Guojia Xie, Di Zhang, Yongfeng Shang, and Jing Liang*. Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27. Journal of Biological Chemistry, 286: 42414-42425, 2011.

9. Jing Liang, Hua Zhang, Yu Zhang, Ying Zhang, and Yongfeng Shang*. GAS, a novel glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function. EMBO Reports, 10: 51-57, 2009.

10. Jing Liangand Yongfeng Shang*. Estrogen and cancer. Annual Review of Physiology. 75: 225-240, 2013.

11. Jing Liangand Yongfeng Shang. Chapter 4: Epigenetic Mechanisms of Cancer Metastasis. Nuclear Signaling Pathways and Targeting Transcription in Cancer. Springer, 2013. Rakesh Kumar Editor