李扬副教授  博士生导师

威尼斯商人电影免费观看干细胞研究中心

联系方式：中心实验楼Q206（办公室）Q203（实验室）

liyang@bjmu.edu.cn或yangli@pku.edu.cn

受教育经历

2003/09-2007/07, 威尼斯商人电影免费观看，基础医学院，博士，导师：李凌松教授

2000/09-2003/07, 内蒙古大学，生命科学院，硕士，导师：旭日干院士

1996/09-2000/07, 内蒙古农业大学，生物工程系，学士

工作经历

2014/08-今, 威尼斯商人电影免费观看，副教授

2014/09-2016/08, 加拿大多伦多大学，Sunnybrook研究所，博士后，

合作导师：Juan Carlos Zuniga-Pflucker 教授

2007/08-2014/08, 威尼斯商人电影免费观看，讲师

研究方向

人多能干细胞（ES，iPS）罕见病模型的构建

人多能干细胞分化的分子调控机制

人多能干细胞定向NK、T细胞分化在肿瘤免疫治疗中的应用

讲授课程

医学细胞生物学，高级细胞生物学，干细胞生物学，细胞生物学研究方法与技术

论文发表*Corresponding Author  ^#Co-first author

(24) Chen E^#, Brauer P^#, Martinez E, Huang X, Yu Y, Anderson M, , Li Y*, Zuniga-Pflucker JC*. T-cell receptor β-selection is required at the CD4⁺CD8⁺ stage of human T cell development. Journal of Immunology. 2021. 206: 2271-2276.

(23) Zhou S^#, Wu J^#, Huang X, YuN, Zou X, SinghJ, Bo Song B*, Li Y*.Cellular uptake of a cationic amphiphilic fluorophore in the form of assemblies via Clathrin-dependent endocytosis. Materials & Design.2021; 200: 109464.

(22) YiS, HuangX, ZhouY,ZhouS, AndersonM, Zuniga-Pflucker JC, LuanQ*, LiY*.E2A regulates neural ectoderm fate specification in human embryonic stem cells. Development. 2020;147: dev190298.

(21) Zhou S^#, Zhao H^#, Feng R^#, Ding L, Li Z, Deng C, He Q, Liu Y*, Song B*,Li Y*. Application of amphiphilic fluorophore-derivednanoparticles to provide contrast to human embryonic stem cells without affecting their pluripotency and to monitor their differentiation into neuron-like cells. Acta Biomaterialia. 2018; 15:274-284.

(20) Abulaiti X^#, Zhang H^#, Wang A, Li N, Li Y, Wang C*, Du X, Li L*. Phosphorylation of Threonine³⁴³ is crucial for OCT4 interaction with SOX2 in the maintenance of mouse embryonic stem cell pluripotency.Stem Cell Reports. 2017; 9: 1630-1641.

(19) Li Y^#, Brauer P^#, Jastaranpreet S, Xhiku S, Yoganathan K, Zuniga-Pflucker JC*, Anderson M*. Targeted disruption in TCF12 reveals HEB as an essential for human mesodermal specification and hematopoiesis. Stem Cell Reports. 2017; 9: 779-795.

(18) Zhou S^#, Liu Y^#, Feng R^#, Wang C, Lan F*, Li Y*. Survivin improves reprogramming efficiency of human neural progenitors by single molecule OCT4. Stem Cells International. 2016; 4729535.

(17) Yan X*, Xu N, Meng C, Wang B, Yuan J, Wang C, Li Y*. Generation of induced pluripotent stem cells from human mesenchymal stem cells of parotid gland origin. Am J Transl Res. 2016; 8:419-432.

(16) Li Y^#, Qiu C^#, Tu J^#, Geng B, Yang J, Jiang T*, Cui Q*. HMDD v2.0: a database for experimentally supported human microRNA and disease association. Nucleic Acids Res. 2014; 38, D119-122.

(15) Li Y,Li X, Zhao H, Feng R, Zhang X, Tan J*.Efficient induction of pluripotent stem cells from menstrual blood. Stem Cells Dev. 2013; 22: 1147-1158.

(14) Li Y*, CangM, Lee A, Zhang K, Liu D*. Reprogramming of sheep fibroblasts into pluripotency under a drug-inducible expression of mouse-derived defined factors. PLoS ONE. 2011.6(1):e15947.

(13)Li Y, Liu Z, Dong C, He P, Liu X, Jia B, Wang F*. Noninvasive Detection of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Teratoma with and Integrin-Targeting Agent (99m)Tc-3PRGD2. Mol Imaging Biol. 2013; 15:58-67.

(12)Li Y, Li Z, Zhou S, Geng B, Yang J, Cui Q*. Genome-wide analysis of human microRNA stability. BioMed Research International. 2013; 2013: 368975.

(11)Li Y, Wan H, Lan B, Xu X, Liu Y, Kong L, Li Y, Feng R, Jiang S, Tan J*. PDGF mediated derivation of human embryonic germ cells.Differentiation. 2013; 8: 141-148.

(10)Liu Y^#,Li Y^#, Hwang A, Wang SY, Jia CW, Yu L, Li J*. Comparison of three embryo culture methods for derivation of human embryonic stem cells from discarded embryos.Cellular Reprogramming. 2011; 13: 233-239.

(9)Li Y^#, Zhao H^#, Lan F^#, Lee A, Chen L, Lin C, Yao Y, Li L*. Generation of human induced pluripotent stem cells from gut mesentery-derived cells by ectopic expression of OCT4/SOX2/NANOG. Cellular Reprogramming. 2010; 12: 237-247.

(8)Zhao H^#, Li Y^#, Jin H, Xie L, Liu C, Jiang F, Luo Y, Yin G, Li Y, Wang J, Li L, Yao Y, Wang X*. Rapid and efficient reprogramming of human amnion-derived cells into pluripotency by three factors OCT4 /SOX2/NANOG. Differentiation. 2010; 80: 123-129.

(7)Li Y, Tan J, Li L*. Comparison of three methods for cryopreservation of human embryonic stem cells. Fertil Steril. 2010; 93:999-1005.

(6)Chen Y^#, Li Y^#, Chen L, Yang X, Su P, Cai J*. The infarcted cardiac microenvironment cannot selectively promote embryonic stem cell differentiation into cardiomyocytes. Cardiovascular Pathology. 2011; 20:77-83.

(5)Li Y*^#, Chi X^#, Li X^#, Xu J. Multipotency of human neural stem cells from fetal striatum. Neuroreport. 2008; 19:1679-1683.

(4)Li Y^#, Lin C^#, Wang L^#, Liu Y, Mu X, Ma Y, Li L*. Maintenance of human embryonic stem cells on gelatin. Chinese Science Bulletin. 2009; 54: 4214-4220.

(3)Tan J^#*, Li Y^#, Qu W, Liu L, Jiang L, Sun K. Derivation of embryonic stem cell line from frozen human embryos and neural differentiation. Neuroreport. 2008; 19:1451-1455.

(2) 李扬，郭继彤，吴凯峰，旭日干*；牛胎儿成纤维细胞的分离与体外培养，细胞生物学杂志，2002，24（4）：254-256

(1) 李扬，吴凯峰，郭旭东，郭继彤，旭日干*；脂质体介导外源基因体外转染牛胎儿成纤维细胞条件的优化，遗传，2002，24（6）：653-655